Mature Lymphocytes

Lymphocytes 1-4 (Canine 1 -4) ARROWS
Lymphocytes. Canine.
Lymphocytes 9-10 (Equine 1-2) ARROWS
Lymphocytes. Equine.
Lymphocytes 5-8 (Bovine 1 -4) ARROWS
Lymphocytes. Chromocenters (arrowheads) may be present in large lymphocytes in cattle. Bovine.

Morphology: small round leukocytes with round or indented nuclei, dark clumped chromatin, and small amounts of light blue cytoplasm. Cattle have small lymphocytes (as described), as well as large lymphocytes with dark areas in the nucleus (chromocenters) and abundant pale blue cytoplasm. T-lymphocytes and B-lymphocytes usually cannot be differentiated on routine blood smears, except for plasma cells and granular lymphocytes (which are either cytotoxic T-cells or natural killer cells).

Look alike: nucleated red blood cells, monocytes

Clinical relevance: small numbers of lymphocytes are seen in the blood of healthy animals (lymphocytes are the predominant leukocyte in cattle). Lymphocytosis (↑ lymphocytes in peripheral blood) may be associated with chronic antigenic stimulation (bacterial, viral, rickettsial infections or vaccination), extreme excitement or stress (epinephrine release), or lymphocytic leukemias (lymphocyte morphology may be abnormal).

Lymphoctes 11 (Canine 5) ARROWS
Lymphocyte. Canine.
Lymphocytes 13 (Canine 7) ARROWS
Lymphocyte (arrow). Acanthocytes, microcytes, polychromatophils, hypochromasia, and platelets also visible (not marked). Canine (iron deficiency anemia).
Lymphocytes 12 (Canine 6) ARROWS
Lymphocyte (arrow). Neutrophil (arrowhead). Polychromatophils, microcytes, hypochromasia, and platelets also visible (not marked). Canine (iron deficiency anemia).
Lymphocytes 14 (Sheep 1) ARROWS
Lymphocytes. Dall’s Sheep.
Lymphocytes 16 (Musk Ox 1 - Microcytic Hypochromic Anemia) ARROWS
Lymphocyte (arrow). Polychromatophils with basophilic stippling also visible (not marked). Musk ox (microcytic hypochromic anemia).
Lymphocytes 15 (Goat 1) ARROWS
Lymphocyte (arrow). Monocytes (arrowheads). Neutrophils (circled). Goat.

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