LGL
Large granular lymphocytic leukemia (LGL): rare form of leukemia secondary to lymphoma. Primary tumors (large granular lymphosarcoma) usually arise in the abdominal cavity (spleen, liver, GI tract, lymph nodes). Secondary… Read more LGL →
CLL
Chronic lymphocytic leukemia (CLL): increased numbers of small mature lymphocytes with normal morphology on blood smear. CLL may look identical to non-neoplastic lymphocytosis on visual evaluation (non-neoplastic causes of lymphocytosis… Read more CLL →
ALL
Acute lymphocytic/lymphoblastic leukemia (ALL): markedly increased numbers of immature lymphoblasts on blood smear (lymphocytosis usually greater than 150 x 109/L). Lymphoblasts are large cells with prominent nucleoli and dark blue… Read more ALL →
Reactive Lymphocytes
Morphology: reactive lymphocytes have a heterogenous appearance with variable size, nuclear shape, and amount and color of cytoplasm. Compared to non-reactive lymphocytes, reactive lymphocytes are usually larger with darker blue cytoplasm,… Read more Reactive Lymphocytes →
Lymphocytic Leukemias
Lymphoid neoplasia is the most common form of hematopoeitic neoplasia in domestic animals. Lymphoid neoplasia can be categorized as lymphosarcomas (neoplastic lymphocytes from solid tumors in extramedullary tissue) or leukemias (neoplastic lymphocytes… Read more Lymphocytic Leukemias →
Granular Lymphocytes
Morphology: lymphocytes with pink or red cytoplasmic granules. Granular lymphocytes are either cytotoxic T-cells or natural killer cells. Look alike: granulocytes (eosinophils, basophils) Clinical relevance: present in low numbers in healthy animals… Read more Granular Lymphocytes →
Mature Lymphocytes
Morphology: small round leukocytes with round or indented nuclei, dark clumped chromatin, and small amounts of light blue cytoplasm. Cattle have small lymphocytes (as described), as well as large lymphocytes with… Read more Mature Lymphocytes →
Cells and Smears 