Agglutination

Agglutination 1 (Canine 1) ARROWS
Agglutination (arrows). Polychromatophils also visible (not marked). Canine (immune-mediated hemolytic anemia).

Morphology: three-dimensional clumps of red blood cells. Caused by antibodies binding red blood cells together.

Look alike: rouleaux. Agglutination can be distinguished from rouleaux with a saline dilution test: place one drop of blood on a slide, add 4 – 10 drops of 0.9% NaCl, examine the slide as a wet mount with a coverslip. Saline dilution will disperse rouleaux but not agglutination.

Clinical relevance: usually indicates immune-mediated hemolytic anemia (IMHA).

Agglutination 2 (Canine 2) ARROWS
Agglutination. Canine.

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