Macrocytes

Macrocytes 2 (Canine 2 - Macrocytic Normochromic Anemia) ARROWS
Numerous macrocytes (examples marked with arrows). Normal red blood cell (arrowhead) for comparison. Canine (macrocytic normochromic anemia).

Morphology: red blood cells that are larger than normal, may be hypochromic or normochromic.

Look alike: polychromatophils (also larger than normal but stain dark purple).

Commonly seen with: other features of regenerative anemia (polychromatophils, anisocytosis, basophilic stippling).

Clinical relevance: commonly associated with regenerative anemia. In horses, macrocytosis may be the only observable feature of regenerative anemia. May be normal in Poodles. Macrocytosis usually corresponds to increased mean cell volume (MCV) on CBC.

Macrocytes 1 (Canine 1 - Macrocytic Normochromic Anemia) ARROWS
Numerous macrocytes (examples marked with arrows). Normal red blood cell (arrowhead) for comparison. Polychromatophils and platelets also visible (not marked). Canine (macrocytic normochromic anemia).

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