Acanthocytes

Acanthocytes 1 (Canine - HSA1) ARROWS
Acanthocytes. Canine (hemangiosarcoma).

Morphology: red blood cells with irregular spicules projecting from the cell surface. Spicules are variable in shape (blunt or bulbous tips), variable in size, and unevenly distributed around the periphery of the cell.

Look alike: echinocytes

Clinical relevance: may be associated with certain underlying disorders including hemangiosarcoma (dogs), liver disease (dogs and cats), disseminated intravascular coagulation (dogs), vasculitis (dogs), iron deficiency anemia (dogs). May also be observed in animals on high lipid diets. Small numbers may be normal in young ruminants (calves).

Acanthocytes vs Echinocytes ARROWS
Left: acanthocytes (arrows) showing irregular spicules that vary in shape and size and are unevenly distributed around the periphery of the cell. Right: echinocytes (arrowheads) with small uniform spicules evenly distributed around the periphery of the cell. Canine.
Acanthocytes 2 (Canine - HSA2) ARROWS
Acanthocytes. Canine (hemangiosarcoma).
Acanthocytes 3 (Canine 1) ARROWS
Acanthocytes. Blue tint likely due to age of preserved smear. Canine.
Acanthocytes 4 (Canine 2) ARROWS
Acanthocytes (arrows). Neutrophil also visible (not marked).Blue tint likely due to age of preserved smear. Canine.
Acanthocytes 6 (Canine 3 - Iron Deficiency) ARROWS
Acanthocyte (arrow). Ruptured keratocyte (arrowhead). Canine (iron deficiency).
Acanthocytes 7 (Canine 4 - Iron Deficiency) ARROWS
Numerous acanthocytes (examples marked with arrows). Lymphocyte (arrowhead). Microcytes, polychromatophils, hypochromasia, and platelets also visible (not marked). Canine (iron deficiency anemia).
Acanthocytes 8 (Rabbit 1 - High Cholesterol Diet) ARROWS
Numerous acanthocytes (examples marked with arrows). Polychromatophils also visible (not marked). Rabbit (high cholesterol diet).
Acanthocytes 5 (Rabbit) ARROWS
Acanthocytes (arrows). Lymphocyte and polychromatophils also visible (not marked). Rabbit.

 

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